SAHVAI Lab & HEADS-UP (CODE ICH) Hemorrhage Tools

Subarachnoid Hemorrhage Volume (SAHV), ICH/IVH Calculators and Volumetric Tools • Freeman & Föttinger et al.
Subject Information
1 Suprasellar Cistern (SSTV)
SSTV0.000 mL
2 Perimesencephalic Cistern (PMTV)
Right
Left
PMTV (R + L)0.000 mL
3 Prepontine Cistern (PPTV)
PPTV0.000 mL
4 Sylvian Cistern (SYTV)
Right
Left
SYTV (R + L)0.000 mL
5 Interhemispheric Fissure (ITV)
ITV0.000 mL
DCI Risk Assessment
SAHV >10 mL associated with higher risk of delayed cerebral ischemia (Freeman & Föttinger, JAHA 2024)
Enter measurements to assess
6 Intraparenchymal Hemorrhage (IPH) & Subdural Hematoma (SDH)

IPH

Right
Left
IPH Total0.000 mL

SDH (ABC/2 ÷ 2)

Right
Left
SDH Total0.000 mL

TOTAL SAHV — 5-Space Cisternal Volume

0.000 mL

6-Space Total (All + IPH/SDH)

0.000 mL

IPH + SDH Combined

0.000 mL
Clinical Notes
Note: The “8th Space” is defined as a gyral-sulcal space that is generally too small to contribute any significant volume (cm³). The quadrigeminal cistern was not included in our measurements.
Anatomic Reference — SAHVAI 5 Cisternal Spaces + 2 Intra-Axial (IPH/ICH) + IVH Model
SAHVAI 7-Space anatomic overview showing 5 cisternal spaces plus IPH and IVH compartments Collapsed view of basal cisterns on CT with color-coded regions Representative CT slices with ABC/2 formula — V_SAH = (H × W × L)/2 × 10^-3

Click any image to enlarge. Images from Freeman & Föttinger ABC/2-derived SAHV method.

Anatomic Definitions of Cisternal Spaces
RegionDefinition
1. Suprasellar cisternRegion around the cranial sella turcica, under the hypothalamus and between the uncus of the temporal lobes
2. Perimesencephalic cisternRegion of the ambient cistern and crural cistern, extending in a crescent-shaped manner along the lateral aspect of the mesencephalon
3. Prepontine cisternRegion extending ventrally over the most caudal segment to the most cranial part of pons
4. Sylvian cisternal complexRegion of the Sylvian cistern containing the lateral projection of the suprasellar cistern (along the temporal pole), the cistern of lateral cerebral fossa and its occipital projection into the Sylvian fissure; anterior part sits between the fronto-orbital cortex and the temporal lobe
5. Anterior interhemispheric cisternRegion cranioventral to suprasellar cistern, until leveled with frontal horn of lateral ventricle
6. IPHIntraparenchymal hemorrhage (IPH), or intracerebral hemorrhage (ICH)
7. IVH / SDH / EDHIntraventricular hemorrhage (IVH) is semi-quantitatively measured by modified Graeb, and/or subdural hematoma (SDH), or epidural hemorrhage (EDH) components are measured by a modified ABC/2 formula using maximal EDH/SDH thickness and length as A and B, and vertical dimensions as C (Freeman et al., Neurocrit Care 2008; PMID: 18392784)
8. Gyral-sulcal SAH blood (not measured)Generally too small to contribute significant volume; not included in the above 5-compartment SAHV ABC/2 model by Föttinger/Freeman et al.
ABC/2-Derived Volume Formula
VSAH(mL) = (A × B × C × slice thickness) / 2 × 10−3
A = maximal length of SAH in the respective cisternal compartment (mm)
B = maximal thickness/width of SAH (mm)
C = number of vertical NCHCT slices with SAH × slice thickness (mm)
For bilateral structures (Perimesencephalic, Sylvian, IPH, SDH), right and left are measured independently and summed.
Key SAHVAI Publications
1. The ABCs of Subarachnoid Hemorrhage Blood Volume Measurement: A Simplified Quantitative Method Predicts Outcomes and Delayed Cerebral Ischemia
Föttinger F, Sharma R, Salman SD, Weston AD, Erickson BJ, Huynh T, Tawk RG, Freeman WD
J Am Heart Assoc. 2024;13(20):e032195
DOI: 10.1161/JAHA.123.032195 • PMID: 39392139
Original ABC/2-derived SAHV method. Demonstrated comparability to manual segmentation (n=277). SAHV >10 mL cutoff predicts DCI and poor outcomes.
2. SAHVAI-3D and 4D: Automated AI Volumetric Measurement of Subarachnoid Hemorrhage on Noncontrast Head CT
Wirtz M, Salman S, Wei Y, Patel VN, Sharma R, Gupta V, Gu Q, Dherin B, Reddy S, Tawk RG, Erickson BJ, Freeman WD
Stroke Vasc Interv Neurol. 2025;5(3):e001620
DOI: 10.1161/SVIN.124.001620 • PMID: 41573412
AI automation of SAHV (SAHVAI). 6.7 seconds vs >60 min manual. 99.8% accuracy, Dice 0.701. 3D brain maps and 4D temporal tracking.
3. External Multicenter Validation of the eSAH Score for Predicting Outcomes After Subarachnoid Hemorrhage
de Oliveira Souza NV, Sharma R, de Toledo OF, Marques IP, Gutierrez-Aguirre SF, et al., Freeman WD
Sci Rep. 2025;16(1):4218
External validation of eSAH score (n=472) across US and Brazil centers. AUC 0.78 for unfavorable outcome, 0.799 for mortality. Each point = 2.14× odds of poor outcome.
4. The eSAH Score: A Simple Practical Predictive Model for SAH Mortality and Outcomes
Sharma R, Mandl D, Föttinger F, Salman SD, Godasi R, Wei Y, Tawk RG, Freeman WD
Sci Rep. 2024;14(1):30753
Development of eSAH score (0–5) combining age, GCS, and SAHV. AUC: 0.89 (mRS), 0.75 (DCI), 0.88 (mortality). Derivation cohort n=277.
5. Bridging Continents, Closing Gaps: A Multicenter Cohort Study on Subarachnoid Hemorrhage Outcomes and Health Care Disparities
de Oliveira Souza NV, Sharma R, de Toledo OF, Marques IP, Föttinger F, et al., Freeman WD
Neurocrit Care. 2026 (online ahead of print)
Multicenter cohort (n=1,145) from Brazil & USA. Documents disparities in SAH outcomes: higher mortality in Brazil (23.4% vs 13.4%), longer time to treatment (77.7 vs 4.3h). SAHV recognition could accelerate equitable care globally.
6. Computer-Assisted Volumetric Analysis Compared With ABC/2 Method for Assessing Warfarin-Related Intracranial Hemorrhage Volumes
Freeman WD, Barrett KM, Bestic JM, Meschia JF, Broderick DF, Brott TG
Neurocrit Care. 2008;9(3):307–12
Compared ABC/2 to computer-assisted volumetric analysis in warfarin-related ICH (n=8). ABC/2 accurately estimates smaller ellipsoid IPH and SDH without requiring an additional ÷2 correction. Larger, complex-shaped hematomas may be underestimated by ABC/2.
7. Evaluation of Explainable Artificial Intelligence for Subarachnoid Hemorrhage Detection and Outcome Modelling Using Neuroimaging Data
Morgan S, Salman S, Walker J, Tawk R, Freeman WD
Sci Rep. 2026 (published online 28 Oct 2026; early access)
SAHDAI-XAI: a cloud-based (Google Cloud AutoML) classifier of noncontrast head CT as SAH-positive or negative, trained on progressively larger datasets (20–300 images; precision 100% in the small early rounds, 97.9% and 94.4% in the larger later rounds), with BLAST-CT hemorrhage maps to explain its predictions and reduce the black-box problem.
Article metadata retrieved from PubMed and the publishers' sites. IVH measured using the Modified Graeb Score per Morgan TC et al., Stroke 2013;44(3):635-41 (doi:10.1161/STROKEAHA.112.670653).

Enhanced SAH (eSAH) Score Calculator

Weighted score (0–5) combining Age, GCS, and SAHV. AUC = 0.89 (mRS), 0.88 (mortality). Sharma, Freeman et al., Sci Rep 2024.

0
Low risk — eSAH 0: favorable outcomes expected
Validated: AUC 0.78 (unfavorable outcome), 0.799 (mortality) across US & Brazil (de Oliveira Souza, Freeman et al., Sci Rep 2025). Each +1 point = OR 2.14 for poor outcome.
Intraventricular Hemorrhage — Modified Graeb Score

Morgan TC, Dawson J, Spengler D, et al. Stroke. 2013;44(3):635-41. doi:10.1161/STROKEAHA.112.670653
Score range: 0–32. Higher scores indicate greater IVH burden.

VentricleScore (0–4)Expansion (0/1)
Left Lateral (frontal horn)
Right Lateral (frontal horn)
Left Lateral (body)
Right Lateral (body)
Left Lateral (temporal horn)
Right Lateral (temporal horn)
Third Ventricle
Fourth Ventricle
Modified Graeb Score 0 / 32

HEADS-UP — intracranial hemorrhage detector, step 1 of the suite

Hemorrhage Evaluation and Detector System for Underserved Populations (Salman et al., Mayo Clin Proc Digit Health 2023). Drop a non-contrast head CT to detect hemorrhage and classify epidural, intraparenchymal, intraventricular, subarachnoid and subdural blood slice by slice, with the RSNA 2019 1st-place networks. It then sends the scan to the segmentation tab that suits the type found. Runs locally, including on a phone browser — images are never uploaded.

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Research use only — not a medical device and not a triage system.

SAHVAI Web — AI hemorrhage segmentation in your browser

Drag and drop a non-contrast head CT (DICOM study, folder or zip, NIfTI or NRRD) to segment SAH, IPH and IVH and measure their volumes with the Hybrid 2D/3D UNet (Hu et al., NeuroImage 2023). The model runs locally on your GPU or CPU — images are never uploaded.

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Research use only — not a medical device. Embedded below, CPU mode runs on one thread; open full screen for multi-threaded CPU (WebGPU is fast in both).

SAHVAI 3D-4D — rotate the hemorrhage in 3D and track it over time

Drop a non-contrast head CT to see SAH, IPH and IVH in a rotatable 3D brain with the skull removed, alongside axial, coronal and sagittal slices. Drop 2–6 serial CTs of the same patient to chart SAHV, IPH, IVH and total blood volume by scan date (SAHVAI-4D; Wirtz et al., Stroke Vasc Interv Neurol 2025). Segmentation by the BrainHemoAI Hybrid 2D/3D UNet, run locally — images are never uploaded.

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Research use only — not a medical device. Embedded below, CPU mode runs on one thread; open full screen for multi-threaded CPU (WebGPU is fast in both).

CLAIM aSAH — multiclass segmentation in your browser

The aneurysmal SAH nnU-Net of the CLAIM group, Charité Berlin (Kiewitz et al., Front Neurol 2024): SAH, IVH, ventricles, ICH, aneurysm and SDH. Weights CC BY-NC 4.0 (non-commercial). The model runs locally on your GPU or CPU — images are never uploaded.

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Research and education use only — not a medical device. Embedded below, CPU mode runs on one thread; open full screen for multi-threaded CPU (WebGPU is fast in both).

BLAST-CT — traumatic brain injury lesions in your browser

The TBI lesion model of the University of Cambridge and Imperial College London (Monteiro et al., Lancet Digit Health 2020): intraparenchymal and extra-axial haemorrhage, oedema and IVH — for SAH after a fall or traumatic ICH. Apache-2.0. Runs locally; images are never uploaded.

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Research and education use only — not a medical device. Embedded below, CPU mode runs on one thread; open full screen for multi-threaded CPU (WebGPU is fast in both).

DeepBleed — ICH segmentation in your browser

The open-source 3D V-Net for intracerebral hemorrhage from the MISTIE trial investigators at Johns Hopkins (Sharrock et al., Neuroinformatics 2021): ICH + IVH segmentation and volume, trained on MISTIE II and validated on MISTIE III. CC BY-NC 4.0 (non-commercial), with the permission of Dr Matthew Sharrock. Runs locally; images are never uploaded.

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Research and education use only — not a medical device. Embedded below, CPU mode runs on one thread; open full screen for multi-threaded CPU (WebGPU is fast in both).

ICH Expansion Signs — CT predictors of hematoma expansion in your browser

Drop a head CT with a spontaneous ICH: the hemorrhage is segmented with SAHVAI, then the expansion signs are read inside and around the hematoma — blend, black hole, hypodensity, swirl, island, satellite, irregular shape, heterogeneous density and fluid level on non-contrast CT, spot-sign candidates on CTA — with the BAT, BRAIN and target expansion scores (the last needs the CTA spot sign, from a CTA run or the reader) and the image patches of the DeepMedX end-to-end expansion pipeline (Yu et al., npj Digit Med 2026). The spot, leakage and iodine signs are referenced with their definitions (Liu et al., GeroScience 2026). Runs locally; images are never uploaded.

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Research and education use only — not a medical device. Signs are rule-based candidates for a reader to confirm. Embedded below, CPU mode runs on one thread; open full screen for multi-threaded CPU (WebGPU is fast in both).

BRAIN Score — predicted risk of ICH growth at 24 hours

Bedside score from five items available at the first CT; no images needed. Predicts clinically significant hematoma growth (≥ 6 mL absolute increase from baseline to 24 h). Derived in the INTERACT2 CT substudy (n = 964) and validated in INTERACT1 (n = 346; C-statistic 0.73, Hosmer–Lemeshow P = 0.82). To score a scan automatically, use the AI tool below, which fills in volume and IVH from the segmentation.

BRAIN score
– / 24
Predicted probability of ICH growth ≥ 6 mL at 24 h
–
Select all five items. Partial: 0 points.
Points → predicted probability (Figure 1 of the paper)
Interpreting the score. Probabilities are from the development model. In INTERACT2 the median predicted probability was 16.4% (IQR 7.7–27.2%) and 18.8% of patients had growth ≥ 6 mL; in the INTERACT1 validation cohort it was 9.3% (IQR 5.1–16.6%). The cohorts were adults with spontaneous ICH enrolled within 6 h of onset with systolic BP 150–220 mmHg; over 90% of the validation cohort was Chinese, the CTA spot sign was not assessed, and the anticoagulant item was derived for warfarin (other oral anticoagulants were not studied). Volume categories follow the paper (planimetric volume; ABC/2 is an approximation). Research and education use only — not a medical device.
Reference
Wang X, Arima H, Al-Shahi Salman R, et al; INTERACT Investigators. Clinical prediction algorithm (BRAIN) to determine risk of hematoma growth in acute intracerebral hemorrhage. Stroke. 2015;46(2):376-381. doi:10.1161/STROKEAHA.114.006910. PMID: 25503550
Target Expansion Score — late presenters (2–12 h from onset)

Imaging-based “target expansion criteria” for patients first imaged 2–12 h after onset or last seen well, by analogy with target mismatch in ischemic stroke. Three items from NCCT and CTA give a 0–4 score; a score ≥ 2 meets the target expansion criteria. Outcome: hematoma expansion > 33% and/or > 6 mL from baseline to follow-up NCCT (24–72 h). Derived and internally validated in a retrospective multicenter cohort from Italy, Germany and China (n = 345 development, 147 validation; AUC 0.77 and 0.79).

Baseline ICH volume (mL)
Onset or last seen well → NCCT (h)
uHG: enter volume and time. High uHG (> 10 mL/h) scores 1.
Spot or serpiginous focus within the hematoma, > 1.5 mm, > 120 HU or ≥ twice the background hemorrhage, no matching NCCT hyperdensity, not connected to a vessel.
Derivation population (flags only; the score is still shown)
Target expansion score
– / 4
–
Observed expansion at this score (development cohort)
–
Complete all three items.
Expansion rate and mean growth by score (Table 5 of the paper)
ScoreDevelopment (n = 345)Validation (n = 147)
HE, n/N (%)Mean growthHE, n/N (%)Mean growth
013/132 (9.8%)0.9 mL3/51 (5.9%)4.3 mL
121/123 (17.1%)3.9 mL10/55 (18.2%)6.7 mL
228/58 (48.3%)11.5 mL12/24 (50.0%)11.2 mL
317/24 (70.8%)13.0 mL3/6 (50.0%)19.5 mL
47/8 (87.5%)26.9 mL8/11 (72.7%)21.2 mL
< 234/255 (13.3%)2.3 mL13/106 (12.3%)5.5 mL
≥ 252/90 (57.8%)13.3 mL23/41 (56.1%)15.1 mL

Score ≥ 2: sensitivity 0.61, specificity 0.85 (development); 0.64 and 0.84 (validation). Adjusted ORs: high uHG 3.44, NCCT hypodensities 2.51, CTA spot sign 8.97.

Interpreting the score. These are observed rates in small strata (only 8 and 11 patients scored 4), not model probabilities, and the authors describe the findings as exploratory pending external validation. Imaging was read locally rather than by a core laboratory, and the study was retrospective with split-sample internal validation only. The cohort excluded anticoagulated patients, brainstem ICH, baseline volume ≥ 100 mL and patients without baseline CTA, so the score needs a CTA. Hematoma expansion did not count IVH growth. When onset was unclear, time was taken from last seen well. Volume was measured by semiautomated planimetry; ABC/2 is an approximation. Research and education use only — not a medical device.
Reference
Morotti A, Pensato U, Nawabi J, et al. Intracerebral hemorrhage expansion in late presenters: proposed target expansion criteria. Neurology. 2026;107(9):e218675. doi:10.1212/WNL.0000000000218675. PMID: 42879724

SAH Swin UNETR — Valladolid blood segmentation in your browser

The Swin transformer blood-segmentation model of the Río Hortega University Hospital group in Valladolid (García-García, Cepeda et al., World Neurosurg 2024), from their open SAH mortality-prediction pipeline: SAH blood and its extensions, with volume. Academic non-commercial licence; hosted with the permission of Dr Santiago Cepeda. Runs locally; images are never uploaded.

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Research and education use only — not a medical device. A large model (277 MB) that runs on the CPU: open full screen for multi-threaded speed (about 1–2 minutes per scan).

RHUH SAH dataset — compare a model with expert masks

Open aSAH CT scans with expert bleeding masks from Río Hortega University Hospital, Valladolid (Cepeda & García-García, Zenodo 2023, CC BY 4.0). Load a case and its mask, run SAHVAI (BrainHemoAI), CLAIM, BLAST-CT or the Valladolid SAH Swin UNETR, and see Dice and volumes. Data stay on your computer.

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Research and education use only — not a medical device. Embedded below, CPU mode runs on one thread; open full screen for multi-threaded CPU (WebGPU is fast in both).

Research Dataset — your site's hemorrhage volumetric data

Every tool (and the ABC/2 calculator) can add a scan to a de-identified dataset kept in this browser. Review it, add outcomes, and export it for REDCap, NIH ScHARe, Parquet, FHIR, OMOP or Convex. Nothing is uploaded.

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Collect and share under your institution's approvals. Research and education use only — not a medical device.

SAHVAI-MM (MultiModal) Calculator

Integrated outcome prediction combining eSAH, CHESS, NLR, and SAHV–DCI risk

e eSAH Score — Mortality & Poor Outcome Prediction

Weighted score (0–5) combining Age, GCS, and SAHV. AUC = 0.89 (mRS), 0.88 (mortality). Auto-fills from Calculator tab if populated, or enter directly below.

eSAH Score
0/5
—
Mortality Risk
—
Poor Outcome (mRS 4–6)
Enter Age, GCS, and SAHV to calculate eSAH
Scoring: Age >55 (+1 pt) | GCS 8–12 (+1 pt), 3–7 (+2 pts) | SAHV 10–20 mL (+1 pt), >20 mL (+2 pts)
5-Cistern SAHV
0.000 mL
Age / GCS
— / —
Mod. Graeb (IVH)
0 / 32
C CHESS Score — Shunt Dependency Risk

Hydrocephalus risk after SAH. Predicts need for ventriculoperitoneal shunt.

CHESS Score 0 / 8
Shunt dependency risk: Low
N Neutrophil-to-Lymphocyte Ratio (NLR)

Inflammatory biomarker predicting DCI. NLR >12.03 cutoff (AUC 0.805).

NLR —
Enter neutrophil and lymphocyte counts
SAHV-Based DCI Risk
Calculated from Calculator tab SAHV
∑ MultiModal Clinical Summary
eSAH Mortality
—
CHESS Shunt Risk
—
NLR DCI Risk
—
Overall Risk
—
Monitoring Recommendation: Enter clinical data to generate multimodal risk profile.
Based on validated scores: eSAH (Sharma/Freeman, Sci Rep 2024), CHESS (Diesing et al.), NLR & SAHV-DCI (Föttinger/Freeman, JAHA 2024). For research and clinical decision-support only.
SAHVAI Calculator v1.0 • © Freeman & Föttinger • Mayo Clinic SAHVAI Laboratory
For research and clinical decision-support purposes. Not a substitute for clinical judgment.
Article metadata from PubMed. Built from SAHVAI MODEL 1 Excel Score Sheet (1.30.2026 final).